Named one of The New Yorker's BEST BOOKS OF 2022 SO FAR

The next frontier in technology is inside our own bodies.

Synthetic biology will revolutionize how we define family, how we identify disease and treat aging, where we make our homes, and how we nourish ourselves. This fast-growing field—which uses computers to modify or rewrite genetic code—has created revolutionary, groundbreaking solutions such as the mRNA COVID vaccines, IVF, and lab-grown hamburger that tastes like the real thing.  It gives us options to deal with existential threats: climate change, food insecurity, and access to fuel.

But there are significant risks.

Who should decide how to engineer living organisms? Whether engineered organisms should be planted, farmed, and released into the wild? Should there be limits to human enhancements? What cyber-biological risks are looming? Could a future biological war, using engineered organisms, cause a mass extinction event? 

Amy Webb and Andrew Hessel’s riveting examination of synthetic biology and the bioeconomy provide the background for thinking through the upcoming risks and moral dilemmas posed by redesigning life, as well as the vast opportunities waiting for us on the horizon.


“[A] fascinating survey of the present and future of biotechnology.” —Nature
“[A] road map for navigating [synthetic biology’s] opportunities and perils.” —The New Yorker
“The book is a brilliant narrative of the future of human life. Webb and Hessel explain the complex matter in such a way that experts and laypeople alike can follow, whose biology lessons were a while ago.” —Handelsblatt
“[A] thought-provoking introduction to synthetic biology…[a] breathtaking science, but it is also scary. Who's in charge, and where are the brakes?” —Booklist
“[D]eeply researched but accessible prose… A wrinkle on the near future that many readers will not have pondered—and should.” —Kirkus
The Genesis Machine is a brilliant pairing of two visionaries who offer us a comprehensive take on making a better world through biology.” —Jane Metcalfe, cofounder of Wired and CEO of NEO.LIFE
The Genesis Machine is a very readable story about how the DNA world is shifting from reading the genetic code to writing and editing it. Amy Webb and Andrew Hessel then take the reader on a journey of possible world changing events that could result from this new technology.” —J. Craig Venter, PhD, author of Life at the Speed of Life: From the Double Helix to the Dawn of Digital and CEO of JCVI
“This spectacular and highly accessiblebook clearly and thoughtfully examines the most important revolution of our lives––and of life itself. Understanding how we and future generations will use the tools of synthetic biology to transform the worlds inside and around us is essential to being an informed and empowered person and citizen in the twenty-first century. The Genesis Machine is a guide to exactly that and a must-read book.” —Jamie Metzl, member of WHO expert committee on human genome editing and author of Hacking Darwin: Genetic Engineering and the Future of Humanity
“You may not realize it yet, but your life—and all of life itself—is about to change. From programmable genes to designer medicines, synthetic biology is going to transform everything. The Genesis Machine is a surprisingly intimate, incisive, and readable guide to the opportunities, risks, and moral dilemmas of the brave new world ahead.” —Steven Strogatz, Cornell University, author of Infinite Powers
The Genesis Machine is a tour de force! Amy Webb and Andrew Hessel masterfully reveal the emerging network of forces—people, labs, computer systems, government agencies, and businesses—that will drive humanity’s next great transformation. Their fascinating (and frightening) conclusions—that the human ecosystem can actually become programmed—will touch every facet of our lives in the future. This brilliant work is an absolute must-read for national security professionals and defense planners who need to understand the complex dynamics at play in the future competition for bio-hegemony.” —Dr. Jake Sotiriadis, chief futurist, United States Air Force
“We can now program biological systems like we program computers, with artificial intelligence and machine learning accelerating the speed of innovation and applications of synthetic biology. In an accessible and fascinating narrative, The Genesis Machine lays out a roadmap for this interdisciplinary field of synthetic biology that is forever reshaping life as we know it.” —Rana el Kaliouby, author of Girl Decoded: A Scientist’s Quest to Reclaim Our Humanity by Bringing Emotional Intelligence to Technology and deputy CEO, Smart Eye
“Are latest innovations in synthetic biology simply a miracle that ends a crisis or a breakthrough to an entirely new way of living? That’s the question futurist Amy Webb and microbiologist Andrew Hessel reveal for us with this fascinating book. The history of the world is a history of unintended consequences, for better and for worse, and Webb and Hessel capture the coming fusion of tech and biology in vivid detail.” —Ian Bremmer, author of Collision Course
The Genesis Machine is fantastic, explaining how genetic code is the alphabet in which much of the future will be written. Amy Webb and Andrew Hessel have taken the very complicated subject of synthetic biology and made it understandable with sharp prose and sharp analysis that cut through mysteries of science and twenty-first-century humanism.” —Alec Ross, author of The Industries of the Future and The Raging 2020s
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